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KMID : 0378019690120050059
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New Medical Journal
1969 Volume.12 No. 5 p.59 ~ p.68
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Progressive Muscular Dystophy
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安華鏞/Ahn, Hwa Young
尹承鎬/崔昌度/Yun, Seung Ho/Choi, Chang Do
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Abstract
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Progressive muscular dystrophy is a primary degenerative disease of skeletal muscles without evidence of regeneration. Since Aran reported on progressive muscular dystrophy in 1850, many authors have studied this disease clinically and experimentally.
This disease causes a bilateral and symmetrical distribution of muscular atrophy. Males are more commonly affected in the ratio of 6:1. The characteristic laboratory findings are increased "creation of creatine and decreased creatinine in the urine.
The microscopic findings in ;the muscle fibers consist of swelling, fragmentation, atrophy and degeneration by vacuolation or granular degeneration. Fat cells accumulate in the large amounts between the musclefibers.
During the last several years, many studies have been attempted in order to determine the basic pathology in the aspect of;
1. histopathological problems,
2. histochemistry and biochemistry
3. serum enzyme activity.
Although various remedies have been used clinically and experimentally to treat the disease. No significant results, however, have been reported.
Recently the importance of physical therapy has been emphasized and in addition psychological, emotional, educational and occupational aspects should be considered.
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